_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant®, a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage®, commercially available software that is based (...) on NeuroQuant® and extends its utility in several ways. Studies using these and similar methods have found that most patients with chronic mild or moderate traumatic brain injury have brain volume abnormalities, and several of these studies found—surprisingly—more abnormal enlargement than atrophy. More generally, 102 peer-reviewed studies have supported the reliability and validity of NeuroQuant® and NeuroGage®. Furthermore, this updated version of a previous review addresses whether NeuroQuant® and NeuroGage® meet the Daubert standard for admissibility in court. It concludes that NeuroQuant® and NeuroGage® meet the Daubert standard based on their reliability, validity, and objectivity. Due to the improvements in technology over the years, these brain volumetric techniques are practical and readily available for clinical or forensic use, and thus they are important tools for detecting signs of brain injury. (shrink)

This study explores how the democratic deficit of the United Nations can be progressively minimized by the development of a global parliamentary body.

Pavlovian cues predict the occurrence of motivationally salient outcomes, thus serving as an important trigger of approach and avoidance behavior. The amygdala is a key substrate of Pavlovian conditioning, and the nature of its contribution varies by the motivational valence of unconditioned stimuli. The literature on aversive Pavlovian learning supports a serial-processing model of amygdalar function, while appetitive studies suggest that Pavlovian associations are processed through parallel circuits in the amygdala. It is proposed that serial and parallel forms of information (...) processing can be attributed to differential recruitment of amygdalar nuclei, with emphasis placed on the lateral amygdala. (shrink)

The term intersectionality, which is generally attributed to Kimberlé Crenshaw, began as a metaphorical and conceptual tool used to highlight the inability of a single-axis framework to capture the lived experiences of black women. Whilst many disciplines have used the ‘tools’ of intersectionality before 1989, modern day usage of the term is usually associated with Crenshaw’s specific approach. The development of Crenshaw’s intersectionality, originated from the failure of both feminist and anti-racist discourse; to represent and capture the specificity of the (...) discrimination faced by black women. This failure resulted from an inability to identify the multiple grounds which constitute an... (shrink)

What, precisely, is `salt'? It is a certainwhite, solid, crystalline, material, alsocalled sodium chloride. Does any of that solidwhite stuff exist in the sea? – Clearly not.One can make salt from sea water easily enough,but that fact does not establish thatsalt, as such, is present in brine. (Paper andink can be made into a novel – but no novelactually exists in a stack of blank paper witha vial of ink close by.) When salt dissolves inwater, what is present is no (...) longer `salt' butrather a collection of hydrated sodium cationsand chloride anions, neither of which isprecisely salt, nor is the collection. Theaqueous material in brine is also significantlydifferent from pure water. Salt may beconsidered to be present in seawater, but onlyin a more or less vague `potential' way.Actually, there is no salt in the sea. In bothancient and modern treatments of otherimportant chemical concepts, including thenotions of `element', related complication,especially polysemy (terms with multiplemeanings), also occurs.In a recent paper, Paul Needham discussed the(predicable) properties of chemical substances,phases, and solutions. He provided a valuablecharacterization of cases in which severalquantities occupy the same space. He alsoconcluded that solution properties are not`intensive', because solvent and solute do nothave parts in common. He tacitly assumed thatingredients are not altered by their inclusionin a solution. This may be the case in somespecial cases (deutero-benzene dissolved inbenzene, say) but is not true in general – andcertainly does not apply to the case of brine,which Needham used as an example – since theions that exist in the solution, and also theaqueous material there, are quite differentfrom the pure ingredients used in making thesolution. An adequate theory of wholes andparts (mereology) must take into account thatwhen individuals enter combinations ofinteresting sorts they no longer are the verysame individuals that existed prior to thecomposition. It appears that no such formaltheory now actually exists. (shrink)

In 1931 eminent chemist Fritz Paneth maintained that the modern notion of “element” is closely related to (and as “metaphysical” as) the concept of element used by the ancients (e.g., Aristotle). On that basis, the element chlorine (properly so-called) is not the elementary substance dichlorine, but rather chlorine as it is in carbon tetrachloride. The fact that pure chemicals are called “substances” in English (and closely related words are so used in other European languages) derives from philosophical compromises made by (...) grammarians in the late Roman Empire (particularly Priscian [fl. ~520 CE]). When the main features of the constitution of isotopes became clear in the first half of the twentieth century, the formal (IUPAC) definition of a “chemical element” was changed. The features that are “essential” to being an element had previously been “transcendental” (“beyond the sphere of consciousness”) but, by the mid-twentieth century the defining characteristics of elements, as such, had come to be understood in detail. This amounts to a shift in a “horizon of invisibility” brought about by progress in chemistry and related sciences. Similarly, chemical insight is relevant to currently-open philosophical problems, such as the status of “the bundle theory” of the coherence of properties in concrete individuals. (shrink)

While engaging in rich discussion, Conspiracy Theories analyzes current arguments and evidence while providing real-world examples so students can contextualize and visualize the debates. Each chapter addresses important current questions, provides conceptual tools, defines important terms, and introduces the appropriate methods of analysis.

Intra-molecular connectivity (that is, chemical structure) does not emerge from computations based on fundamental quantum-mechanical principles. In order to compute molecular electronic energies (of C 3 H 4 hydrocarbons, for instance) quantum chemists must insert intra-molecular connectivity “by hand.” Some take this as an indication that chemistry cannot be reduced to physics: others consider it as evidence that quantum chemistry needs new logical foundations. Such discussions are generally synchronic rather than diachronic —that is, they neglect ‘historical’ aspects. However, systems of (...) interest to chemists generally are metastable . In many cases chemical systems of a given elemental composition may exist in any one of several different metastable states depending on the history of the system. Molecular structure generally depends on contingent historical circumstances of synthesis and separation, rather than solely or mainly on relative energies of alternative stable states, those energies in turn determined by relationships among components. Chemical structure is usually ‘kinetically-determined’ rather than ‘thermodynamically-determined.’ For instance, cyclical hydrocarbon ring-systems (as in cyclopropene) are produced only in special circumstances. Adequate theoretical treatments must take account of the persistent effects of such contingent historical events whenever they are relevant—as they generally are in chemistry. (shrink)

One of the main functions that introductory chemistry courses have fulfilled during the past century has been to provide evidence for the general validity of 'the atomic hypothesis.' A second function has been to demonstrate that an analytical approach has wide applicability in rationalizing many kinds of phenomena. Following R.G. Collingwood, these two functions can be recognized as related to a philosophical 'cosmology' (worldview, weltanshauung) that became dominant in the later Renaissance. Recent developments in many areas of science, and in (...) chemistry, have emphasized the central importance of understanding synthetic, developmental, and evolutionary aspects of nature. This paper argues that these scientific developments, and changes in other aspects of culture, amount to a widespread shift to an alternative cosmology, a quite different general worldview. To the extent that this is the case, introductory chemistry courses ought to be changed in fundamental ways. Rather that having a main focus on analysis to microscopic components, introductory chemistry instruction should emphasize current scientific understanding of the (synthetic) evolutionary origins of the present world. This altered approach would provide good preparation for future professional work, while also making better contact with the perceived concerns of students. (shrink)

This volume addresses relations between macroscopic and microscopic description; essential roles of visualization and representation in chemical understanding; historical questions involving chemical concepts; the impacts of chemical ideas on wider cultural concerns; and relationships between contemporary chemistry and other sciences. The authors demonstrate, assert, or tacitly assume that chemical explanation is functionally autonomous. This volume should he of interest not only to professional chemists and philosophers, but also to workers in medicine, psychology, and other fields in which relationships between explanations (...) based on diverse levels of description and investigation are important. (Listed on Google books). (shrink)

The work is the presentation of a logical theory - Logic in Reality (LIR) - and of applications of that theory in natural science and philosophy, including ...

Longlisted for the PEN/E.O. Wilson Literary Science Writing Award A leading neuroscientist offers a history of the evolution of the brain from unicellular organisms to the complexity of animals and human beings today Renowned neuroscientist Joseph LeDoux digs into the natural history of life on earth to provide a new perspective on the similarities between us and our ancestors in deep time. This page-turning survey of the whole of terrestrial evolution sheds new light on how nervous systems evolved in (...) animals, how the brain developed, and what it means to be human. In The Deep History of Ourselves, LeDoux argues that the key to understanding human behavior lies in viewing evolution through the prism of the first living organisms. By tracking the chain of the evolutionary timeline he shows how even the earliest single-cell organisms had to solve the same problems we and our cells have to solve each day. Along the way, LeDoux explores our place in nature, how the evolution of nervous systems enhanced the ability of organisms to survive and thrive, and how the emergence of what we humans understand as consciousness made our greatest and most horrendous achievements as a species possible. (shrink)

'Fear' is used scientifically in two ways, which causes confusion: it refers to conscious feelings and to behavioral and physiological responses. Restricting the use of 'fear' to denote feelings and using 'threat-induced defensive reactions' for the responses would help avoid misunderstandings about the brain mechanisms involved.

Combinations of molecules, of biological individuals, or of chemical processes can produce effects that are not simply attributable to the constituents. Such non-redundant causality warrants recognition of those coherences as ontologically significant whenever that efficacy is relevant. With respect to such interaction, the effective coherence is more real than are the components. This ontological view is a variety of structural realism and is also a kind of process philosophy. The designation ‘process structural realism’ (PSR) seems appropriate.

Fact checking has become a prominent facet of political news coverage, but it employs a variety of objectionable methodological practices, such as treating a statement containing multiple facts as if it were a single fact and categorizing as accurate or inaccurate predictions of events yet to occur. These practices share the tacit presupposition that there cannot be genuine political debate about facts, because facts are unambiguous and not subject to interpretation. Therefore, when the black-and-white facts—as they appear to the fact (...) checkers—conflict with the claims produced by politicians, the fact checkers are able to see only (to one degree or another) “lies.” The examples of dubious fact-checking practices that we discuss show the untenability of the naïve political epistemology at work in the fact-checking branch of journalism. They may also call into question the same epistemology in journalism at large, and in politics. (shrink)

Nature abounds in compound individuals. Discrete, functioning entities are made up of components which are, in some sense, also individuals. Scientists sometimes need to be concerned with whether aggregates (e.g.. species of plants) or components (e.g., quarks) exist. but such questions are not generally regarded as having great importance for science. It has often happened, however, that scientific developments have had major significance for subsequent philosophical discussion of problems of the one and the many. Recently, there has been considerable increase (...) in scientific understanding of spontaneous development of spatial and temporal organization (structure) in physical. chemical, and biological systems. In an earlier note (PS 11:35), I suggested that this progress in science raises points that may be helpful in dealing with a question of current importance for process philosophy. This paper provides support for that suggestion. The first section introduces the philosophical problem. The middle sections provide brief non-technical introduction to scientific concepts. The final section combines both topics. (shrink)

ABSTRACT The main cause of the crisis was the behavior of the banks—largely a result of misguided incentives unrestrained by good regulation. Conservative ideology, along with unrealistic economic models of perfect information, perfect competition, and perfect markets, fostered lax regulation, and campaign contributions helped the political process along. The banks misjudged risk, wildly overleveraged, and paid their executives handsomely for being short‐sighted; lax regulation let them get away with it—putting at risk the entire economy. The mortgage brokers neglected due diligence, (...) since they would not bear the risk of default once their mortgages had been securitized and sold to others. Others can be blamed: the ratings agencies that judged subprime securities as investment grade; the Fed, which contributed low interest rates; the Bush administration, whose Iraq war and tax cuts for the rich made low interest rates necessary. But low interest rates can be a boon; it was the financial institutions that turned them into a bust. (shrink)

The main idea in this series of essays is that subjective awareness depends upon the intralaminar nuclei of each thalmus. This implies that the internal structure and external relations of ILN make subjective awareness possible. An array of material relevant to this proposal was briefly reviewed in Part I. This Part II considers in more detail some semantic aspects and a bit of philosophic background as these pertain to propositions 0, 1, and 2 of Part I. Part II should be (...) read in conjunction with Part I. (shrink)

In the characterization of the ArCl2 'van der Waals complex', a recognizable pattern of well-defined peaks is observed in the microwave absorption spectrum. In the control of chaos in a chemical oscillatory reaction the power spectrum progressively becomes simpler, at length yielding a single peak. Since both of these cases generate coherences that are centers of agency, they should be considered to produce new chemical entities. Applicability of this ontological approach to coherences of wider societal interest is suggested.

When a group of processes achieves such closure that a set of states of affairs recurs continually, then the effect of that coherence on the world differs from what would occur in the absence of that closure. Such altered effectiveness is an attribute of the system as a whole, and would have consequences. This indicates that the network of processes, as a unit, has ontological significance. Whenever a network of processes generates continual return to a limited set of states of (...) affairs, the system may function as a “whole”— with respect to appropriate interaction partners. The balance achieved by the processes provides the form of definiteness of a unified agent. The causal powers of such coherent aggregates are indeed just the powers of the “constituents acting in concert”. However, the components act in concert in the specific way they do only because of their inclusion in the closed set of interactions that defines the coherence. This renders the causal powers of the coherence defined by that closure non-redundant, and hence the coherence, as a unit, is ontologically significant. The form of definiteness that provides internal coherence also grounds external efficacy of the societal aggregation. The closure is a structural feature of the coherence — possibly, but not necessarily, apparent in spatial structuring. This approach can provide a unified account that includes quantum microphysics, systems biology, and the philosophy of organism ─ without reducing any of these to another. (shrink)

Philosophers have long debated ‘substrate’ and ‘bundle’ theories as to how properties hold together in objects ― but have neglected to consider that every chemical entity is defined by closure of relationships among components ― here designated ‘Closure Louis de Broglie.’ That type of closure underlies the coherence of spectroscopic and chemical properties of chemical substances, and is importantly implicated in the stability and definition of entities of many other types, including those usually involved in philosophic discourse ― such as (...) roses, statues, and tennis balls. Characteristics of composites are often presumed to ‘supervene on’ properties of components. This assumption does not apply when cooperative interactions among components are significant. Once correlations dominate, then adequate descriptions must involve different entities and relationships than those that are involved in ‘fundamental-level’ description of similar but uncorrelated systems. That is to say, descriptions must involve different semantics than would be appropriate if cooperative interactions were insignificant. This is termed ‘Closure Henri Poincaré. Networks of chemical reactions that have certain types of closure of processes display properties that make other more-complex coherences possible. This is termed ‘Closure Jacques Cauvin.’ Each of these three modes of closure provides a sufficient basis for warranted recognition of causal interaction, thus each of them has epistemological significance. Other modes of epistemologically-important closure probably exist. It is important to recognize that causal efficacy generally depends on closure of relationships of constituents. (shrink)

This article grapples with the causes of India’s microfinance crisis. By contrasting Bangladesh’s highly successful Grameen model with the allegedly “universalizable” version of India’s SKS Microfinance, trust or social capital is isolated—not just narrowly interpreted within standard economic theory, but more broadly construed—as the essential element accounting for the early success of microfinance. It is argued that the microfinance experience has been widely misinterpreted, in both analytical and policy terms. This article suggests inherent limits in extending the model to for-profit (...) institutions and, in particular, to the pace of scaling up. (shrink)

How certain neural mechanisms momentarily endow with the subjective awareness percepts and affects represented elsewhere is more likely to be clarified when structures essential to Mc are identified. The loss of C with bilateral thalmic lesions involving the intralaminar nuclei contrasts with retention of C after large cortical ablations depriving C of specific contents. A role of ILN in the perception of primitive sensations is suggested by their afference of directly ascending pathways. A role for ILN in awareness of cortical (...) activity is suggested by their widespread afference from cortex, a property shared with striatum. A role for ILN in volition is suggested by their heavy projection to striatum. Unlike striatum, ILN also project widely to almost all neocortex, enabling an effect on ideation; this last property is in common with other structures but none of them has the same direct cortical afference. And passage through the reticular nucleus of ILN efferents to cortex could impact the attention-selective action of nRt. It is suggested that the quickest route to a better understanding of C involves more intensive study of ILN. No other structure seems, in the light of our current knowledge, a more likely site for Mc. (shrink)

This paper recommends that chemistry educators shift to a different ‘idea of nature’, an alternative ‘worldview.’ Much of contemporary science and technology deals in one way or another with dynamic coherences that display novel and important properties. The notion of how the world works that such studies and practices generate (and require) is quite different from the earlier concepts that are now integrated into science education. Eventual success in meeting contemporary technological and social challenges requires general diffusion of an overall (...) outlook that focuses on creative generation of novel and useful coherences, replacing a worldview that concentrates on analysis of pre-existing items to minimum constituents. Such a shift in emphasis would amount to general adoption of a new basic model of how nature functions. Chemistry educators can and should provide leadership for this urgently-needed development. (shrink)

Bertrand Russell was perhaps the last great philosopher to take an active interest in economics. After a brief, youthful engagement with the economics of socialism in 1889, Russell wrote on economic questions in three separate periods up to 1918, and in each case there was a clear political motivation. The first, in 1895–96, arose from his investigation of Marxism as a creed and of German social democracy as its principal contemporary political expression. The second, in 1903–04, was provoked by his (...) intervention on the free trade side of the tariff controversy. Finally, in 1915–18, Russell's commitment to Guild Socialism and to war resistance led him to some profound, if rather speculative, reflections on the economics of libertarian socialism. In this paper I discuss each of these three phases in Russell's economic thought and conclude that he never went far enough in his opposition to neo-classical theory in general, or to its utilitarian foundations in particular. (shrink)

The advent of quantum mechanics in the early 20 th Century had profound consequences for science and mathematics, for philosophy (Schrödinger), and for logic (von Neumann). In 1968, Putnam wrote that quantum mechanics required a revolution in our understanding of logic per se. However, applications of quantum logics have been little explored outside the quantum domain. Dummett saw some implications of quantum logic for truth, but few philosophers applied similar intuitions to epistemology or ontology. Logic remained a truth-functional ’science’ of (...) correct propositional reasoning. Starting in 1935, the Franco-Romanian thinker Stéphane Lupasco described a logical system based on the inherent dialectics of energy and accordingly expressed in and applicable to complex real processes at higher levels of reality. Unfortunately, Lupasco’s fifteen major publications in French went unrecognized by mainstream logic and philosophy, and unnoticed outside a Francophone intellectual community, albeit with some translations into other Romance languages. In English, summaries of Lupasco’s logic appeared ca. 2000, but the first major treatment and extension of his system was published in 2008 (see Brenner 2008). This paper is a further attempt to establish Lupasco’s concepts as significant contributions to the history and philosophy of logic, in line with the work of Gödel, general relativity, and the ontological turn in philosophy. (shrink)

ABSTRACTMichelle Amazeen's rebuttal of Uscinski and Butler 2013 is unsuccessful. Amazeen's attempt to infer the accuracy of fact checks from their agreement with each other fails on its own terms and, in any event, could as easily be explained by fact checkers’ political biases as their common access to the objective truth. She also ignores the distinction between verifiable facts and unverifiable claims about the future, as well as contestable claims about the causes of political, social, and economic phenomena. The (...) social benefits that she claims for the fact-checking enterprise must, at the very least, be weighed against the strong possibility that what passes for fact checking is actually just a veiled continuation of politics by means of journalism rather than being an independent, objective counterweight to political untruths. (shrink)

Ecology and sustainability are current narratives about the behavior of humans toward themselves and the environment. Ecology is defined as a science, and a philosophy of ecology has become a recognized domain of the philosophy of science. For some, sustainability is an accepted, important moral goal. In 2013, a Special Issue of the journal Sustainability dealt with many of the relevant issues. Unfortunately, the economic, ideological, and psychological barriers to ethical behavior and corresponding social action remain great as well as (...) obvious. In this paper, I propose that a new, non-standard and non-propositional logic of real processes, Logic in Reality grounded in physics applies to the science and philosophy of these narratives and helps to explicate them. Given the ecological role of organizations and institutions, reference is often made to organizational or institutional logics as guides to ecological practice. This paper suggests that these logics are either too abstract or too informal to have an impact in a conflictual world. Recognition of the suggested new, transdisciplinary logical dimension of ecological processes may provide credibility and support to new initiatives in ecology and its philosophy. (shrink)

During a long and distinguished career, Belgian physical chemist Ilya Prigogine (1917–2003) pursued a coherent research program in thermodynamics, statistical mechanics, and related scientific areas. The main goal of this effort was establishing the origin of thermodynamic irreversibility (the ‘‘arrow of time’’) as local (residing in the details of the interaction of interest), rather than as global (being solely a consequence of properties of the initial singularity – the ‘‘Big Bang’’). In many publications for general audiences, he stated the opinion (...) that this scientific research had great philosophical importance. Prigogine and his colleagues considered that the most recent stages of this research program have been successful, so that the local origins of the arrow of time are now established. There is no scientific consensus as to whether or not this claim is valid. Similarly, there is no consensus on whether the competing global (initial singularity) explanation has been proven. (shrink)

While it is common to think that neuroscientists are proponents of basic emotions theory, this is not necessarily the case. My ideas, for example are more aligned with cognitive than basic emotions theories.

The conjunction of process and reality is familiar from the original theory of A. N. Whitehead and the subsequent development of process philosophy and metaphysics by Nicholas Rescher. Classical logic, however, is either ignored or stated to be inappropriate to a discussion of process. In this paper, I will show that the value of a process view of reality can be enhanced by reference to a new, transconsistent logic of reality that is grounded in the physical properties of energy in (...) its various forms. These properties justify a principle of dynamic antagonism or opposition that explicates the phenomena of change at all levels of reality. It can be, accordingly, a preferred logic for understanding the dynamics of real processes. (shrink)

Many people believe in the power of positive thinking (i.e., how thoughts and attitude can shape their future) yet, despite a plethora of books on this subject, no previous author has credibly explained how mere thoughts are able to tangibly influence future events. To explain the connection, Dr. Donlan presents a new paradigm of nature coupled with a viable explanation of how our right cerebral hemisphere has evolved circuitry that can tap into the hidden domain of the metaphysical. To support (...) this premise, he exposes the reader to the worlds of physics, metaphysics, brain architecture, and evolution. Donlan then introduces the many problems associated with the current model and contrasts it with a new view which remedies many of the issues facing theoretical physicists today. Important to its central theme, the book's proposed paradigm supports the remarkable notion that the future can only be created with thoughts. In the final analysis, the author brings his readers through the necessary steps to put this knowledge to work to help them (pre)ordain their own realities. (shrink)